I casted with a Tranx for close to 8 hours and loved every cast! I am a natural lefty but have no issues with "big" right handed reels. Moving my left hand down for casting, up for retrieve, and back down for figure 8 is smooth. Haven't got a fish on the fig 8 yet but that may cause me some grief.
Currently I have a Curado 300 DSV and a Calcutta in 400 (with power handle).