You dont say whether this is for a company where you currently work (i.e an interview for a promotion), or for a new company - big difference from an interview perspective. If you already work at the company, then an awful lot is known about you, and you now an awful lot about the position and the company. If it is a new company, completely different approach for the interview for both of you
Be yourself, and tell the truth. If you believe you can do the job, say why you are the right person for it in our answers. Use examples from your experience.
When I am looking for a candidate it is about more than just the skill-sets - especially when it is a leadership position. It's as much a personality thing - does the way you think and do thing match the way we do? If so, do you have the knowledge and skills. At the end of every interview we always ask candidates if they have any questions for us. The ones who ask questions which show they have imagined themselves getting the job always score better, and usually get shortlisted (if they meet the other criteria).
Good luck!