IME it hasn't made much of a difference what line/setup is being used if the bite is on. I can see how with clear water, live bait, species being fished for, lighter line may be useful, but here's an interesting situation:
On our last outing, my wife, myself, Johnnyb, and Laker Jessy were in two canoes. Roughly 10'-20' apart. Both running a Minn Kota Drift Sock out the back, going about the same speed. All of us were using 3" tube jigs, right on bottom for Smallies. I'll ignore jig head size for the moment because I don't have the numbers. I was using 14lb Mono, Johnnyb green power pro (__lb test?), Jessy red power pro (__lb test?), and my wife 10/12?lb flouro. Nicole and I had a small swivel clip at the end of the line for simplicity. I'm going to assume that the power pro's were doing the same for the moment (I'm sure I'll be corrected shortly if I'm wrong). Nicole caught nothing on the fluoro ( a few small ones got off beside the boat); I got a few in the 1-2lb range on the mono; the two running power pro hooked into several, including two over 4lbs.
Doesn't speak volumes for fluoro; nor does it seem the power pro got in the way.
Until someone develops wireless fishing rods, this debate will go on and on...I think it's somewhere on the same list as wireless power bars