I drive it each yeah year for the past 10 yrs or so. I've done both and I prefer the The West Virginia route. Someone mentioned I-95, this is wrong, it's I-90, Buffalo to Erie, toll costs $3.90 US. The West Virginia route is slightly more complicated in that there are more changes in routes, i.e. I-90 to I-79 in Erie, then it's I-77 to I-20, then I-95 and finally on to I-75. There are 2 more tolls but they are minimal, $1.25 and $0.50 (I think). Be careful around Summersville, WV, they love to ticket Canadians for speeding.....a very inhospitable place in my opinion and so I never give the businesses there any of my money. Your GPS will probably take you to Daytona along I-95 to I-4 through Orlando and that's OK. But if you go through I10 in Jaksonville, to 301 then be careful along this route.....plenty of speed traps. The only other matter is weather through Eire and the mountains in WV......pay attention to the forecasts.